BDBM288999 US10092563, Compound 137::US10092563, Compound 138

SMILES Nc1nc(N)c(C#N)c(NC2(CC2)c2nc3c(Cl)ccc(Cl)c3c(=O)n2C2CCC2)n1

InChI Key InChIKey=QPAIBVTXKSJYPG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 288999   

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 4.70E+4nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 5.00E+3nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 2.29E+5nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 5.80E+4nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 1.00E+3nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

LigandPNGBDBM288999(US10092563, Compound 138 | US10092563, Compound 13...)
Affinity DataIC50: 5.24E+5nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent