BDBM288405 US10087187, Compound 106

SMILES Cc1nc2c(N)cc(nn2c1Cc1cccc(F)c1C1CCNCC1)N1CCOCC1

InChI Key InChIKey=QIDVCXQDTQASFN-UHFFFAOYSA-N

Data  4 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 288405   

LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd:  2.75E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd:  0.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd:  372nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd:  5.01E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd: >3.02E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 372nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed