BDBM288356 US10087187, Compound 47

SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCC(C1)S(C)(=O)=O)C(F)(F)F)N1CCOCC1

InChI Key InChIKey=PYQSRCXXTVLWRY-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 288356   

LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd:  1.05E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd:  2.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd:  47nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd:  2.09E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd: >3.02E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent