BDBM287914 Cis[8-(morpholin-4-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][3-(2,2,2-trifluoroethyl)-3-azabicyclo[3.1.1]hept-6-yl]methanone::US10086000, Example 131::US10508108, Example 131

SMILES FC(F)(F)CN1C[C@@H]2C[C@H](C1)[C@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key InChIKey=XSRWMKUIIODORQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287914   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287914(US10086000, Example 131 | Cis[8-(morpholin-4-yl)-5...)
Affinity DataIC50: 114nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287914(US10086000, Example 131 | Cis[8-(morpholin-4-yl)-5...)
Affinity DataIC50: 114nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent