BDBM287865 6-(octahydro-1,4- benzodioxin-2-ylcarbonyl)- 8-(8-oxa-3- azabicyclo[3.2.1]oct-3-yl)- 6,11-dihydro-5H- pyrido[2,3-b] [1,5]benzodiazepine::US10086000, Example 82::US10508108, Example 82

SMILES O=C(C1COC2CCCCC2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CC2CCC(C1)O2

InChI Key InChIKey=BZMCEZPNQMNBRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287865   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287865(US10086000, Example 82 | 6-(octahydro-1,4- benzodi...)
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287865(US10086000, Example 82 | 6-(octahydro-1,4- benzodi...)
Affinity DataIC50: 20nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent