BDBM287864 6-{[(2R)-6-chloro-2,3- dihydro-1,4-benzodioxin- 2-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 81::US10508108, Example 81

SMILES Clc1ccc2O[C@H](COc2c1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key InChIKey=CNDOGTNLWGSFMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287864   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287864(US10086000, Example 81 | 6-{[(2R)-6-chloro-2,3- di...)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287864(US10086000, Example 81 | 6-{[(2R)-6-chloro-2,3- di...)
Affinity DataIC50: 18nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent