BDBM287846 2-methyl-2-[6-(6,7,8,9- tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepin-8- yl]propanenitrile::US10086000, Example 63

SMILES CC(C)(C#N)c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1

InChI Key InChIKey=BTTKTSNRFDGVEO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 287846   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 287846BDBM287846(US10086000, Example 63 | 2-methyl-2-[6-(6,7,8,9- t...)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal His8-tagged human recombinant IDH1 R132H mutant expressed as Escherichia coli BL21 (DE3) cells using alpha KG as substrate p...More data for this Ligand-Target Pair
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Date in BDB:
10/13/2025
Entry Details
PubMed