BDBM287636 US10085984, Example 14::US11040034, Ex. No. 14

SMILES Fc1ccc2nc(-c3cnnc4ccccc34)n(C3CC3)c2c1

InChI Key InChIKey=BXLUDHOXTONJTD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287636   

TargetCytochrome P450 11B2, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287636(US10085984, Example 14 | US11040034, Ex. No. 14)
Affinity DataIC50: 100nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287636(US10085984, Example 14 | US11040034, Ex. No. 14)
Affinity DataIC50: 300nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287636(US10085984, Example 14 | US11040034, Ex. No. 14)
Affinity DataIC50: 50nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287636(US10085984, Example 14 | US11040034, Ex. No. 14)
Affinity DataIC50: 550nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent