BDBM287616 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(7-phenylpyrrolo[1,2-f][1,2,4]triazin-2-ylamino)phenyl)acrylamide::US10085983, Compound J-11

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(-c3ccccc3)n2n1

InChI Key InChIKey=WSAZSRLUAGXQFR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287616   

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287616(US10085983, Compound J-11 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287616(US10085983, Compound J-11 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 10nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent