BDBM286305 5-amino-3-(2-ethoxyquinolin-6- yl)-1-(3-hydroxy-3-methylbutan- 2-yl)-1H-pyrazole-4-carboxamide MS (ESI) (M + H)+ = 384.8::US9518026, Example 98::US9956214, Compound 1636

SMILES CCOc1ccc2cc(ccc2n1)-c1nn(C(C)C(C)(C)O)c(N)c1C(N)=O

InChI Key InChIKey=AMGMAKSGXBFINM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286305   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286305(US9518026, Example 98 | 5-amino-3-(2-ethoxyquinoli...)
Affinity DataIC50: 6nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetUncharacterized protein(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286305(US9518026, Example 98 | 5-amino-3-(2-ethoxyquinoli...)
Affinity DataIC50: 3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286305(US9518026, Example 98 | 5-amino-3-(2-ethoxyquinoli...)
Affinity DataIC50: 58nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286305(US9518026, Example 98 | 5-amino-3-(2-ethoxyquinoli...)
Affinity DataIC50: 18nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent