BDBM286240 4-(3-cyclopropyl-8- fluoroimidazo[1,2-a]pyridin-2- yl)isoquinoline::US9518055, Example 44

SMILES Fc1cccn2c(C3CC3)c(nc12)-c1cncc2ccccc12

InChI Key InChIKey=JKSXZWXLFVIZOH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286240   

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286240(US9518055, Example 44 | 4-(3-cyclopropyl-8- fluoro...)
Affinity DataIC50: 14.5nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286240(US9518055, Example 44 | 4-(3-cyclopropyl-8- fluoro...)
Affinity DataIC50: 2.19E+3nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent