BDBM286099 N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10081635, Example 62

SMILES CCS(=O)(=O)N1CC(N(C)c2ncnc3[nH]ccc23)C2(CC2)C1

InChI Key InChIKey=HQBFYPGGEFCITG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286099   

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 2.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 422nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 198nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent