BDBM286095 (R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile::US10081635, Example 5

SMILES CN([C@H]1CN(CC11CC1)C(=O)CC#N)c1ncnc2[nH]ccc12

InChI Key InChIKey=VCBQNQKWRAHHIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286095   

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 8.5nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 412nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 1.09E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 252nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent