BDBM286046 (S)-2-(Difluoromethyl)-5-(((2-fluoro-2-methyl-propanoyl)amino)methyl)-N-(1-(tetrahydrofuran-3-yl)-2-(4-(trifluoromethyl)phenyl)-1H-indol-5-yl)nicotinamide::US10081629, Example 31

SMILES CC(C)(F)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc1ccc2n([C@H]3CCOC3)c(cc2c1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=PLFPEWKFGGDGPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286046   

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286046(US10081629, Example 31 | (S)-2-(Difluoromethyl)-5-...)
Affinity DataIC50: 2.95nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286046(US10081629, Example 31 | (S)-2-(Difluoromethyl)-5-...)
Affinity DataIC50: 17nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286046(US10081629, Example 31 | (S)-2-(Difluoromethyl)-5-...)
Affinity DataIC50: 17nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286046(US10081629, Example 31 | (S)-2-(Difluoromethyl)-5-...)
Affinity DataIC50: 17nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent