BDBM286023 2-(difluoromethyl)-N-(1-ethyl-2-(4-(trifluoromethyl)phenyl)-1H-indol-5-yl)-5-((2-methylpropanoylamino)methyl)nicotinamide::US10081629, Example 1

SMILES CCn1c(cc2cc(NC(=O)c3cc(CNC(=O)C(C)C)cnc3C(F)F)ccc12)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=OSNVMTSRFZDTBL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286023   

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286023(US10081629, Example 1 | 2-(difluoromethyl)-N-(1-et...)
Affinity DataIC50: 8.26nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286023(US10081629, Example 1 | 2-(difluoromethyl)-N-(1-et...)
Affinity DataIC50: 3.55nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent