BDBM285974 US10081617, Example 121::methyl [4-(2-{(7S)-3-[5-chloro- 2-(4-chloro-1H-1,2,3-triazol-1- yl)phenyl]-7-hydroxy-1-oxido- 6,7-dihydro-5H- cyclopenta[b]pyridin-7-yl}-1H- imidazol-5-yl)phenyl]carbamate

SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@]1(O)CCc2cc(c[n+]([O-])c12)-c1cc(Cl)ccc1-n1cc(Cl)nn1

InChI Key InChIKey=AMNAEUFXYYSMHZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285974   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285974(US10081617, Example 121 | methyl [4-(2-{(7S)-3-[5-...)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
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Date in BDB:
1/12/2019
Entry Details
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