BDBM285902 7-(4-(5-carboxy-4-fluorothiophene-3-yl)-1H-imidazol-2-yl)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine-1-oxide::US10081617, Example 50::US10081617, Example 51

SMILES COC(=O)c4scc(C(=O)COC(=O)C3(O)CCc2cc(c1cc(Cl)ccc1NC(=O)OC(C)(C)C)c[n+]([O-])c23)c4F

InChI Key InChIKey=HVEYBHCKXVTUME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285902   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285902(US10081617, Example 51 | 7-(4-(5-carboxy-4-fluorot...)
Affinity DataIC50: 0.440nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285902(US10081617, Example 51 | 7-(4-(5-carboxy-4-fluorot...)
Affinity DataIC50: 21.4nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent