BDBM285852 5-(2-{3-[5-chloro-2- (1H-tetrazol-1- yl)phenyl]-1-oxido- 6,7-dihydro-5H- cyclopenta[b]pyridin- 7-yl}-1H-imidazol-5- yl)thiophene-2- carboxylic acid::US10081617, Example 12

SMILES OC(=O)c1ccc(s1)-c1cnc([nH]1)C1CCc2cc(c[n+]([O-])c12)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=CJODOARCLRCYGE-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285852   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285852(US10081617, Example 12 | 5-(2-{3-[5-chloro-2- (1H-...)
Affinity DataIC50: 5.94nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285852(US10081617, Example 12 | 5-(2-{3-[5-chloro-2- (1H-...)
Affinity DataKi:  3.08nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent