BDBM285842 (6R,7R,8S)-8-(3-hydroxyprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 24::US9796680, Example 24

SMILES OCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1

InChI Key InChIKey=JGTGAWSDCHTBRU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285842   

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285842(US10081601, Example 24 | (6R,7R,8S)-8-(3-hydroxypr...)
Affinity DataIC50: 17nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285842(US10081601, Example 24 | (6R,7R,8S)-8-(3-hydroxypr...)
Affinity DataIC50: 17nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent