BDBM285841 (6R,7R,8S)-8-(pent-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 23::US9796680, Example 23

SMILES CCCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1

InChI Key InChIKey=USECWGHCBFNPNA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285841   

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285841(US10081601, Example 23 | (6R,7R,8S)-8-(pent-1-yn-1...)
Affinity DataIC50: 6.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285841(US10081601, Example 23 | (6R,7R,8S)-8-(pent-1-yn-1...)
Affinity DataIC50: 6.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent