BDBM285836 (6R,7R,8S)-8-((E)-2-fluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 18::US9796680, Example 18

SMILES O[C@@H]1CNC2(CC2)[C@H](\C=C\F)[C@H]1O

InChI Key InChIKey=OMLFGBKTKHVSQF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285836   

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285836(US10081601, Example 18 | (6R,7R,8S)-8-((E)-2-fluor...)
Affinity DataIC50: 20nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285836(US10081601, Example 18 | (6R,7R,8S)-8-((E)-2-fluor...)
Affinity DataIC50: 20nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent