BDBM285829 (6R,7R,8S)-N-cyclopropyl-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carboxamide::US10081601, Example 11::US9796680, Example 11

SMILES O[C@@H]1CNC2(CC2)[C@@H]([C@H]1O)C(=O)NC1CC1

InChI Key InChIKey=OZMBWHOGRHGGHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285829   

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285829(US10081601, Example 11 | (6R,7R,8S)-N-cyclopropyl-...)
Affinity DataIC50: 462nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Alectos Therapeutics

US Patent
LigandPNGBDBM285829(US10081601, Example 11 | (6R,7R,8S)-N-cyclopropyl-...)
Affinity DataIC50: 462nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent