BDBM285690 6-amino-4-(3-bromo-5-(trifluoromethyl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile ::US10077273, Compound a::US10934305, Compound a

SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Br)cc(c1)C(F)(F)F

InChI Key InChIKey=LAKFZGRXOWFMOU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285690   

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285690(US10077273, Compound a | 6-amino-4-(3-bromo-5-(tri...)
Affinity DataIC50: 42nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285690(US10077273, Compound a | 6-amino-4-(3-bromo-5-(tri...)
Affinity DataIC50: 42nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent