BDBM285679 US10077273, Compound HK-9::US10934305, Compound HK-9

SMILES COc1cc(Cl)cc(c1)C1(C2CCC2)c2c(C)n[nH]c2OC(N)=C1C#N

InChI Key InChIKey=BKJSZNAFWJBAKK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285679   

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285679(US10077273, Compound HK-9 | US10934305, Compound H...)
Affinity DataIC50: 3.46E+3nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285679(US10077273, Compound HK-9 | US10934305, Compound H...)
Affinity DataIC50: 3.46E+3nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent