BDBM285673 US10077273, Compound HK-3::US10934305, Compound HK-3

SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cccc(Cl)c1

InChI Key InChIKey=VENYEPRDCWHPKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285673   

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285673(US10077273, Compound HK-3 | US10934305, Compound H...)
Affinity DataIC50: 1.19E+3nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285673(US10077273, Compound HK-3 | US10934305, Compound H...)
Affinity DataIC50: 1.19E+3nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent