BDBM285668 US10077273, Compound 8::US10584132, Compound 8::US10934305, Compound 8

SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN

InChI Key InChIKey=ABVQWOKKUNIONW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 285668   

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 43nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 8nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 43nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University

US Patent
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 8nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent