BDBM285640 5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl]-4,6-dimethylpyridazin-3(2H)-one::US10077272, Example 6::US9868744, 8

SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C

InChI Key InChIKey=XSXFCXDSCVELLC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285640   

TargetD(1A) dopamine receptor(Human)
Pfizer

US Patent
LigandPNGBDBM285640(US10077272, Example 6 | 5-[4-(furo[2,3-d]pyrimidin...)
Affinity DataKi:  30.7nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Pfizer

US Patent
LigandPNGBDBM285640(US10077272, Example 6 | 5-[4-(furo[2,3-d]pyrimidin...)
Affinity DataKi:  40.2nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Pfizer

US Patent
LigandPNGBDBM285640(US10077272, Example 6 | 5-[4-(furo[2,3-d]pyrimidin...)
Affinity DataKi:  44.7nMpH: 7.4Assay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Pfizer

US Patent
LigandPNGBDBM285640(US10077272, Example 6 | 5-[4-(furo[2,3-d]pyrimidin...)
Affinity DataKi:  44.7nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
Go to US Patent