BDBM285029 N-[3-(2-methyl-1-oxo-6-phenylisoquinolin- 4-yl)phenyl]methanesulfonamide::US10023592, Example 74

SMILES Cn1cc(-c2cccc(NS(C)(=O)=O)c2)c2cc(ccc2c1=O)-c1ccccc1

InChI Key InChIKey=PSPDBKYBDYJXRN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285029   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM285029(US10023592, Example 74 | N-[3-(2-methyl-1-oxo-6-ph...)
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM285029(US10023592, Example 74 | N-[3-(2-methyl-1-oxo-6-ph...)
Affinity DataIC50: 920nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed