BDBM284960 4-(3-aminophenyl)-2- methylisoquinolin-1-one::US10023592, Example 5::US10941160, Example 5

SMILES Cn1cc(-c2cccc(N)c2)c2ccccc2c1=O

InChI Key InChIKey=KVXVYBYTNGEFFS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284960   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM284960(US10023592, Example 5 | 4-(3-aminophenyl)-2- methy...)
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM284960(US10023592, Example 5 | 4-(3-aminophenyl)-2- methy...)
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM284960(US10023592, Example 5 | 4-(3-aminophenyl)-2- methy...)
Affinity DataIC50: 2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
Go to US Patent