BDBM284088 4-(5-(3-cyano-6-(1-methyl-1H- pyrazol-4-yl)pyrazolo[1,5- a]pyridin-4-yl)pyridin-2-yl)- N,N-diethylpiperazine-1- carboxamide::US10023570, Example 98::US10174027, Example 98

SMILES CCN(CC)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=FOPNWPYWGWXGET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284088   

LigandPNGBDBM284088(US10023570, Example 98 | 4-(5-(3-cyano-6-(1-methyl...)
Affinity DataIC50: 3.60nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284088(US10023570, Example 98 | 4-(5-(3-cyano-6-(1-methyl...)
Affinity DataIC50: 3.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284088(US10023570, Example 98 | 4-(5-(3-cyano-6-(1-methyl...)
Affinity DataIC50: 3.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent