BDBM283844 US10023562, Example 36::US10544133, Example 37::US9657009, 37

SMILES COC(C)(C)[C@H](F)CNC(=O)c1cnc(Nc2ncc(cc2F)C#N)cc1NC(C)C

InChI Key InChIKey=JTLRIQVZZHIXPT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 283844   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM283844(US10023562, Example 36 | US9657009, 37 | US1054413...)
Affinity DataIC50: 3.30nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM283844(US10023562, Example 36 | US9657009, 37 | US1054413...)
Affinity DataIC50: 3.30nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM283844(US10023562, Example 36 | US9657009, 37 | US1054413...)
Affinity DataIC50: 4nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM283844(US10023562, Example 36 | US9657009, 37 | US1054413...)
Affinity DataIC50: 3.30nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM283844(US10023562, Example 36 | US9657009, 37 | US1054413...)
Affinity DataIC50: 4nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent