BDBM283673 2-((3-(azetidin-1-yl)quinolin-6-yl)methyl)-N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)isonicotinamide::US10023557, Example 320::US10308637, Example 320

SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)N2CCC2)c1

InChI Key InChIKey=UVBHSNBVAWXQBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283673   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283673(US10023557, Example 320 | 2-((3-(azetidin-1-yl)qui...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283673(US10023557, Example 320 | 2-((3-(azetidin-1-yl)qui...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent