BDBM283143 (2R)—N-[1-{N′-cyano-N-[3-(difluoromethoxy)phenyl]carbamimidoyl}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxypropanamide (1:1 Mixture of Diastereomers)::US10023539, Example 9

SMILES CCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)[C@@H](C)O

InChI Key InChIKey=PTAMOQNBPVQUNA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283143   

TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM283143(US10023539, Example 9 | (2R)—N-[1-{N′-c...)
Affinity DataIC50: 13nMpH: 9.0Assay Description:SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM283143(US10023539, Example 9 | (2R)—N-[1-{N′-c...)
Affinity DataIC50: 2.64nMAssay Description:For the detection of SMYD2 cellular methylation activity an In Cell Western (ICW) assay was established. This assay allows rapid processing of multip...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
Go to US Patent