BDBM282916 6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyclobutyl)-1H-imidazol-5-yl)imidazo[1,2- a]pyridine-3-carboxamide::US10287295, Example 121'::US11352360, Example 121'::US9884868, Example 121'

SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1C1CC(F)(F)C1)-c1ccc(F)c(Cl)c1

InChI Key InChIKey=ZIZAEJSSNOQTAF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 282916   

TargetTGF-beta receptor type-1(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.10nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.10nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282916(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyc...)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
Go to US Patent