BDBM282780 (S)-2-(3-oxo-3H-spiro [isobenzofuran-1,4'-piperidin]-1'- yl)-6-((2-oxopyrrolidin-3- yl)amino)pyrimidine-4- carboxamide::US11180502, Compound 10::US9884865, Compound 10

SMILES NC(=O)c1cc(N[C@H]2CCNC2=O)nc(n1)N1CCC2(CC1)OC(=O)c1ccccc21

InChI Key InChIKey=XRLGCXCLXDFHBO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282780   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM282780((S)-2-(3-oxo-3H-spiro [isobenzofuran-1,4'-piperidi...)
Affinity DataIC50: 3.86E+3nMpH: 7.3Assay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM282780((S)-2-(3-oxo-3H-spiro [isobenzofuran-1,4'-piperidi...)
Affinity DataIC50: 3.86E+3nMAssay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent