BDBM281567 US10022461, Compound 18::US20240165276, Compound MK-6420

SMILES Nc1c(F)ccc2cnc(cc12)-n1ccc2ccncc12

InChI Key InChIKey=KAXAUWZJVWGFDO-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281567   

TargetMicrotubule-associated protein tau(Human)
Karin & Sten Mortstedt Cbd Solutions

US Patent
LigandPNGBDBM281567(US10022461, Compound 18 | US20240165276, Compound ...)
Affinity DataIC50: 1.00E+3nMAssay Description:In the presence of 3 nM of the known tau ligand [3H]-THK5117 (Novandi Chemistry) and 0.2 mM 0N4R tau fibrils in binding buffer (50 mM Tris-HCl, pH 7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Karin & Sten Mortstedt Cbd Solutions

US Patent
LigandPNGBDBM281567(US10022461, Compound 18 | US20240165276, Compound ...)
Affinity DataKi:  0.430nM ΔG°:  -12.8kcal/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent