BDBM281129 US10022354, Example 69

SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cnn(Cc2ccccc2)c1

InChI Key InChIKey=ZMMWAYLSGNDHBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281129   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281129(US10022354, Example 69)
Affinity DataIC50: 0.110nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281129(US10022354, Example 69)
Affinity DataIC50: 105nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed