BDBM281107 US10022354, Example 47

SMILES Cc1cc(cc(n1)C1CCN(C1)C(=O)c1cc(n[nH]1)C1CC1)-c1cnn(C)c1

InChI Key InChIKey=WCOMCPYVSHGEPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281107   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281107(US10022354, Example 47)
Affinity DataIC50: 0.400nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281107(US10022354, Example 47)
Affinity DataIC50: 357nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed