BDBM281088 US10022354, Example 28

SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)NC(=O)C1CC1

InChI Key InChIKey=CXEXTVGTDZRKJS-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 281088   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataIC50: 0.130nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataKd: >1.20E+4nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using biotinylated H3K4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281088(US10022354, Example 28)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed