BDBM280508 US10030020, Example 53::US10781211, Example 53

SMILES COC(=O)C1CCN(CC1)c1cc(ccc1CN1CC2(CC1(C)C)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=OWNOKYOCPSHNLY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 280508   

TargetMonoglyceride lipase(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 550nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 1.00E+3nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD2(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 1.00E+3nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 100nMT: 2°CAssay Description:Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 550nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD6(Mouse)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Abide Therapeutics

US Patent
LigandPNGBDBM280508(US10030020, Example 53 | US10781211, Example 53)
Affinity DataIC50: 100nMAssay Description:Human: Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent