BDBM280478 US10030020, Example 23::US10781211, Example 215

SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(cc3N3CCCCC3)C(F)(F)F)C2)CC1)C(F)(F)F

InChI Key InChIKey=GUZAJWZSXRDQJS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 280478   

TargetMonoglyceride lipase(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 1.00E+3nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD2(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 1.00E+3nMAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 100nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Mouse)
Abide Therapeutics

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD6(Mouse)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 100nMAssay Description:Human: Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM280478(US10030020, Example 23 | US10781211, Example 215)
Affinity DataIC50: 100nMAssay Description:Human: Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent