BDBM28047 (4Z)-6-bromo-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione::CHEMBL407095::isoquinolinedione, 2

SMILES Brc1ccc2C(=O)NC(=O)C(=CNc3ccc(CN4CCCCC4)cc3)c2c1

InChI Key InChIKey=ZTWORKFXUOCZAV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 28047   

TargetInsulin-like growth factor 1 receptor(Human)
Wyeth Research

LigandPNGBDBM28047(CHEMBL407095 | (4Z)-6-bromo-4-({[4-(piperidin-1-yl...)
Affinity DataIC50: 2.89E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28047(CHEMBL407095 | (4Z)-6-bromo-4-({[4-(piperidin-1-yl...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK4/cyclin D1 expressed in Sf9 cells-baculovirus system assessed as retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28047(CHEMBL407095 | (4Z)-6-bromo-4-({[4-(piperidin-1-yl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK1/Cyclin B1 expressed in Sf9 cells-baculovirus system assessed as retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28047(CHEMBL407095 | (4Z)-6-bromo-4-({[4-(piperidin-1-yl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK2/cyclin E expressed in Sf9 cells-baculovirus system assessed as retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed