BDBM280370 2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-pyrazolo[3,4-d]pyrimidin-4-yl}pyridin-4-amine::US10030004, Compound 36::US10501436, Compound 36::US11053216, Compound 36::US11702401, Compound 36

SMILES CC(C)c1cnc(cc1Nc1ncnc2[nH]ncc12)-c1cc(Cl)ccc1F

InChI Key InChIKey=NRALVILIKBNNQX-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280370   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 17.7nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 8.93E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/12/2020
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: 8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
12/30/2018
Entry Details
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