BDBM280367 4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl)pyridin-4-yl]amino}-N-(1,3-dihydroxypropan-2-yl)pyridine-3-carboxamide::US10030004, Compound 33::US10501436, Compound 33::US11053216, Compound 33::US11702401, Compound 33

SMILES OCC(CO)NC(=O)c1cnccc1Nc1cc(ncc1N1CCCC1)-c1cc(Cl)ccc1F

InChI Key InChIKey=FDMRIXRWLAMVEF-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280367   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 78.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 89.6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 78.8nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 89.6nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 78.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 89.6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 78.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 89.6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280367(4-{[2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
12/30/2018
Entry Details
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