BDBM280365 4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyridin-4-yl]amino}-N-[(2S)-2-hydroxypropyl]pyridine-3-carboxamide::US10030004, Compound 31::US10501436, Compound 31::US11053216, Compound 31::US11702401, Compound 31

SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1C1CC1)-c1cc(Cl)ccc1F

InChI Key InChIKey=WQPRHDZTTYJDPW-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280365   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10.5nMMore data for this Ligand-Target Pair

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Date in BDB:
10/12/2020
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/12/2020
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280365(4-{[2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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