BDBM280357 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-[(1S)-1-(hydroxymethyl)propyl]pyridine-3-carboxamide::US10030004, Compound 24a::US10501436, Compound 24a::US11053216, Compound 24a::US11702401, Compound 24a

SMILES CC[C@@H](CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=CKLULXBYHFYPHR-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280357   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 65.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 230nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/18/2023
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 65.3nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 230nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 65.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 230nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 65.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 230nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280357(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
12/30/2018
Entry Details
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