BDBM280351 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-(methane sulfonamido)ethyl]pyridine-3-carboxamide::US10030004, Compound 18::US10501436, Compound 18::US11053216, Compound 18::US11702401, Compound 18

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NCCNS(C)(=O)=O)-c1cc(Cl)ccc1F

InChI Key InChIKey=ATSRJSICZUBQJU-UHFFFAOYSA-N

Data  25 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 280351   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 39nMAssay Description:Inhibition of human ALK5 autophosphorylationMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/18/2024
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
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TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 34.5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 105nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL