BDBM280344 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-4-ylamino)-N-(2-hydroxy propyl)nicotinamide::US10030004, Compound 11a::US10501436, Compound 11a::US11053216, Compound 11a::US11702401, Compound 11a

SMILES CCc1cnc(cc1Nc1ccncc1C(=O)NC[C@H](C)O)-c1cc(Cl)ccc1F

InChI Key InChIKey=OGPVQKHTKOAKDQ-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 280344   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 6.75E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 33.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 86.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 6.75E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 33.5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 86.8nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 6.75E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 33.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 86.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 6.75E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 33.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 86.8nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280344((S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL