BDBM280341 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(1-hydroxypropan-2-yl)nicotinamide::US10030004, Compound 7a::US11053216, Compound 7a::US11702401, Compound 7a

SMILES CC[C@H](O)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=ODWRQIDMGOOEIE-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 280341   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 6.57E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.09E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 13nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 16.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 6.57E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.09E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 16.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 6.57E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.09E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 13nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280341((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)
Affinity DataIC50: 16.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent