BDBM280340 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1-hydroxypropan-2-yl)nicotinamide::US10030004, Compound 6a::US10501436, Compound 6a::US11053216, Compound 6a::US11702401, Compound 6a

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)N[C@@H](C)CO)-c1cc(Cl)ccc1F

InChI Key InChIKey=POMBIFQUJUHXAV-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 280340   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 5.01E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human ALK5 autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 15.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 8.60nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.04E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 5.01E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 15.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 8.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.04E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 5.01E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 15.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 8.60nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.04E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 5.01E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 15.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 8.60nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280340((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)
Affinity DataIC50: 1.04E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent